FHIT (NM_002012) Human Recombinant Protein

• Background:

  The protein encoded by this gene is a P1-P3-bis (5'-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage. [provided by RefSeq, Aug 2017]

• Synonyms:

  AP3Aase; FRA3B

• Gene ID:

  2272

• UniProt:

  P49789, A0A024R366

• Accession Number mRNA:

  NM_002012

• Chromosomal Location:

  3p14.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Non-small cell lung cancer, Purine metabolism, Small cell lung cancer

• Field of Research:

  Non-small cell lung cancer, Purine metabolism, Small cell lung cancer

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Molecular Weight:

  16.7 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  FHIT

• Species:

  Human

• Protein ID:

  NP_002003

• Overview:

  Recombinant protein of human fragile histidine triad gene (FHIT)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/2272

• Uniprot URL:

  https://www.uniprot.org/uniprot/P49789

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_002012

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_002003