PRELP (NM_201348) Human Recombinant Protein

• Background:

  The protein encoded by this gene is a leucine-rich repeat protein present in connective tissue extracellular matrix. This protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage. It also binds the basement membrane heparan sulfate proteoglycan perlecan. This protein is suggested to be involved in the pathogenesis of Hutchinson-Gilford progeria (HGP), which is reported to lack the binding of collagen in basement membranes and cartilage. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

• Synonyms:

  MST161; MSTP161; SLRR2A

• Gene ID:

  5549

• UniProt:

  P51888

• Accession Number mRNA:

  NM_201348

• Chromosomal Location:

  1q32.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Secreted Protein

• Molecular Weight:

  41.6 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  PRELP

• Species:

  Human

• Protein ID:

  NP_958505

• Overview:

  Purified recombinant protein of Homo sapiens proline/arginine-rich end leucine-rich repeat protein (PRELP), transcript variant 2

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/5549

• Uniprot URL:

  https://www.uniprot.org/uniprot/P51888

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_201348

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_958505