CST6 (NM_001323) Human Recombinant Protein

• Background:

  The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. This gene encodes a cystatin from the type 2 family, which is down-regulated in metastatic breast tumor cells as compared to primary tumor cells. Loss of expression is likely associated with the progression of a primary tumor to a metastatic phenotype. [provided by RefSeq, Jul 2008]

• Synonyms:

  ECTD15

• Gene ID:

  1474

• UniProt:

  Q15828

• Accession Number mRNA:

  NM_001323

• Chromosomal Location:

  11q13.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Secreted Protein

• Molecular Weight:

  13.5 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  CST6

• Species:

  Human

• Protein ID:

  NP_001314

• Overview:

  Recombinant protein of human cystatin E/M (CST6)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/1474

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q15828

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001323

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001314