SIGLECL1 (SIGLEC12) (NM_053003) Human Recombinant Protein

• Background:

  Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

• Synonyms:

  S2V; Siglec-XII; SIGLECL1; SLG

• Gene ID:

  89858

• UniProt:

  Q96PQ1

• Accession Number mRNA:

  NM_053003

• Chromosomal Location:

  19q13.41

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Stem cell - Pluripotency, Transmembrane

• Molecular Weight:

  63 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  SIGLEC12

• Species:

  Human

• Protein ID:

  NP_443729

• Overview:

  Recombinant protein of human sialic acid binding Ig-like lectin 12 (SIGLEC12), transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/89858

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q96PQ1

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_053003

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_443729