PTP epsilon (PTPRE) (NM_006504) Human Recombinant Protein

• Background:

  The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Several alternatively spliced transcript variants of this gene have been reported, at least two of which encode a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokine-induced SATA signaling, as well as the activation of voltage-gated K+ channels. [provided by RefSeq, Oct 2015]

• Synonyms:

  HPTPE; PTPE; R-PTP-EPSILON

• Gene ID:

  5791

• UniProt:

  P23469, Q96P81

• Accession Number mRNA:

  NM_006504

• Chromosomal Location:

  10q26.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Phosphatase, Transmembrane

• Molecular Weight:

  80.5 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  PTPRE

• Species:

  Human

• Protein ID:

  NP_006495

• Overview:

  Recombinant protein of human protein tyrosine phosphatase, receptor type, E (PTPRE), transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/5791

• Uniprot URL:

  https://www.uniprot.org/uniprot/P23469

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_006504

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_006495