NYREN18 (NUB1) (NM_016118) Human Recombinant Protein

• Background:

  This gene encodes a protein that functions as a negative regulator of NEDD8, a ubiquitin-like protein that conjugates with cullin family members in order to regulate vital biological events. The protein encoded by this gene regulates the NEDD8 conjugation system post-transcriptionally by recruiting NEDD8 and its conjugates to the proteasome for degradation. This protein interacts with the product of the AIPL1 gene, which is associated with Leber congenital amaurosis, an inherited retinopathy, and mutations in that gene can abolish interaction with this protein, which may contribute to the pathogenesis. This protein is also known to accumulate in Lewy bodies in Parkinson's disease and dementia with Lewy bodies, and in glial cytoplasmic inclusions in multiple system atrophy, with this abnormal accumulation being specific to alpha-synucleinopathy lesions. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]

• Synonyms:

  BS4; NUB1L; NYREN18

• Gene ID:

  51667

• UniProt:

  Q9Y5A7, H3BM14

• Accession Number mRNA:

  NM_016118

• Chromosomal Location:

  7q36.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  68.9 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  NUB1

• Species:

  Human

• Protein ID:

  NP_057202

• Overview:

  Recombinant protein of human negative regulator of ubiquitin-like proteins 1 (NUB1)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/51667

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9Y5A7

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_016118

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_057202