Neuronal calcium binding protein (NECAB3) (NM_031231) Human Recombinant Protein

• Background:

  The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. The protein is phosphorylated by NIMA-related expressed kinase 2, and localizes to the Golgi apparatus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Synonyms:

  APBA2BP; dJ63M2.4; dJ63M2.5; EFCBP3; NIP1; STIP3; SYTIP2; XB51

• Gene ID:

  63941

• UniProt:

  Q96P71

• Accession Number mRNA:

  NM_031231

• Chromosomal Location:

  20q11.22

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Molecular Weight:

  40.6 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  NECAB3

• Species:

  Human

• Protein ID:

  NP_112508

• Overview:

  Recombinant protein of human N-terminal EF-hand calcium binding protein 3 (NECAB3), transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/63941

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q96P71

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_031231

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_112508