Ribonuclease Inhibitor (RNH1) (NM_002939) Human Recombinant Protein

• Background:

  Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]) . In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850) . Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.[supplied by OMIM, Jul 2010]

• Synonyms:

  RAI; RNH

• Gene ID:

  6050

• UniProt:

  P13489, A0A140VJT8

• Accession Number mRNA:

  NM_002939

• Chromosomal Location:

  11p15.5

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Activity:

  25889213

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Molecular Weight:

  49.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  RNH1

• Species:

  Human

• Protein ID:

  NP_002930

• Overview:

  Recombinant protein of human ribonuclease/angiogenin inhibitor 1 (RNH1), transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/6050

• Uniprot URL:

  https://www.uniprot.org/uniprot/P13489

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_002939

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_002930