LXR beta (NR1H2) (NM_007121) Human Recombinant Protein

• Background:

  The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]) .[supplied by OMIM, Jan 2010]

• Synonyms:

  LXR-b; LXRB; NER; NER-I; RIP15; UNR

• Gene ID:

  7376

• UniProt:

  P55055, F1D8P7

• Accession Number mRNA:

  NM_007121

• Chromosomal Location:

  19q13.33

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Activity:

  27489280

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Nuclear Hormone Receptor, Transcription Factors

• Molecular Weight:

  50.9 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  NR1H2

• Species:

  Human

• Protein ID:

  NP_009052

• Overview:

  Recombinant protein of human nuclear receptor subfamily 1, group H, member 2 (NR1H2)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/7376

• Uniprot URL:

  https://www.uniprot.org/uniprot/P55055

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_007121

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_009052