Collagen VI (COL6A1) (NM_001848) Human Recombinant Protein

• Background:

  The collagens are a superfamily of proteins that play a role in maintaining the integrity of various tissues. Collagens are extracellular matrix proteins and have a triple-helical domain as their common structural element. Collagen VI is a major structural component of microfibrils. The basic structural unit of collagen VI is a heterotrimer of the alpha1 (VI), alpha2 (VI), and alpha3 (VI) chains. The alpha2 (VI) and alpha3 (VI) chains are encoded by the COL6A2 and COL6A3 genes, respectively. The protein encoded by this gene is the alpha 1 subunit of type VI collagen (alpha1 (VI) chain) . Mutations in the genes that code for the collagen VI subunits result in the autosomal dominant disorder, Bethlem myopathy. [provided by RefSeq, Jul 2008]

• Synonyms:

  BTHLM1; OPLL; UCHMD1

• Gene ID:

  1291

• UniProt:

  P12109, A0A384P5H7

• Accession Number mRNA:

  NM_001848

• Chromosomal Location:

  21q22.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  ECM-receptor interaction, Focal adhesion

• Field of Research:

  ECM-receptor interaction, Focal adhesion

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Molecular Weight:

  106.4 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  COL6A1

• Species:

  Human

• Protein ID:

  NP_001839

• Overview:

  Recombinant protein of human collagen, type VI, alpha 1 (COL6A1)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/1291

• Uniprot URL:

  https://www.uniprot.org/uniprot/P12109

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001848

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001839