LAP2 (TMPO) (NM_001032283) Human Recombinant Protein

• Background:

  Through alternative splicing, this gene encodes several distinct LEM domain containing protein isoforms. LEM domain proteins include inner nuclear membrane and intranuclear proteins, and are involved in a variety of cellular functions including gene expression, chromatin organization, and replication and cell cycle control. The encoded alpha isoform is broadly diffuse in the nucleus and contains a lamin binding domain, while the beta and gamma isoforms are localized to the nuclear membrane and contain an HDAC3 interaction domain. The distinct isoforms may compete with each other when acting to chaperone other proteins and regulate transcription. [provided by RefSeq, Aug 2019]

• Synonyms:

  CMD1T; LAP2; LEMD4; PRO0868; TP

• Gene ID:

  7112

• UniProt:

  P42167, A0A024RBE7, Q59G12

• Accession Number mRNA:

  NM_001032283

• Chromosomal Location:

  12q23.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Stem cell - Pluripotency, Transmembrane

• Molecular Weight:

  50.5 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  TMPO

• Species:

  Human

• Protein ID:

  NP_001027454

• Overview:

  Recombinant protein of human thymopoietin (TMPO), transcript variant 2

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/7112

• Uniprot URL:

  https://www.uniprot.org/uniprot/P42167

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001032283

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001027454