C15orf38 (ARPIN) (NM_182616) Human Recombinant Protein

• Background:

  Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  C15orf38

• Gene ID:

  348110

• UniProt:

  Q7Z6K5

• Accession Number mRNA:

  NM_182616

• Chromosomal Location:

  15q26.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Molecular Weight:

  24.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  ARPIN

• Species:

  Human

• Protein ID:

  NP_872422

• Overview:

  Recombinant protein of human chromosome 15 open reading frame 38 (C15orf38)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/348110

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q7Z6K5

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_182616

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_872422