BCDIN3D (NM_181708) Human Recombinant Protein

• Background:

  This gene encodes an RNA methyltransferase which belongs to the rossmann fold methyltransferase family, and serves as a 5'-methylphosphate capping enzyme that is specific for cytoplasmic histidyl tRNA. The encoded protein contains an S-adenosylmethionine binding domain and uses the methyl group donor, S-adenosylmethionine. This gene is overexpressed in breast cancer cells, and is related to the tumorigenic phenotype and poor prognosis of breast cancer. The encoded protein is thought to promote the cellular invasion of breast cancer cells, by downregulating the expression of tumor suppressor miRNAs through the dimethylation of the 5-monophosphate of the corresponding precursor miRNAs. [provided by RefSeq, Apr 2017]

• Synonyms:

  BCDIN3 domain containing

• Gene ID:

  144233

• UniProt:

  Q7Z5W3

• Accession Number mRNA:

  NM_181708

• Chromosomal Location:

  12q13.12

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Molecular Weight:

  33 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  BCDIN3D

• Species:

  Human

• Protein ID:

  NP_859059

• Overview:

  Recombinant protein of human BCDIN3 domain containing (BCDIN3D)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/144233

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q7Z5W3

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_181708

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_859059