BCAR1 (NM_014567) Human Recombinant Protein

• Background:

  The protein encoded by this gene is a member of the Crk-associated substrate (CAS) family of scaffold proteins, characterized by the presence of multiple protein-protein interaction domains and many serine and tyrosine phosphorylation sites. The encoded protein contains a Src-homology 3 (SH3) domain, a proline-rich domain, a substrate domain which contains 15 repeat of the YxxP consensus phosphorylation motif for Src family kinases, a serine-rich domain, and a bipartite Src-binding domain, which can bind both SH2 and SH3 domains. This adaptor protein functions in multiple cellular pathways, including in cell motility, apoptosis and cell cycle control. Dysregulation of this gene can have a wide range of effects, affecting different pathways, including cardiac development, vascular smooth muscle cells, liver and kidney function, endothelial migration, and cancer. [provided by RefSeq, Sep 2017]

• Synonyms:

  CAS; CAS1; CASS1; CRKAS; P130Cas

• Gene ID:

  9564

• UniProt:

  P56945

• Accession Number mRNA:

  NM_014567

• Chromosomal Location:

  16q23.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Chemokine signaling pathway, Focal adhesion, Leukocyte transendothelial migration, Regulation of actin cytoskeleton

• Field of Research:

  Chemokine signaling pathway, Focal adhesion, Leukocyte transendothelial migration, Regulation of actin cytoskeleton

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  93.2 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  BCAR1

• Species:

  Human

• Protein ID:

  NP_055382

• Overview:

  Recombinant protein of human breast cancer anti-estrogen resistance 1 (BCAR1)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/9564

• Uniprot URL:

  https://www.uniprot.org/uniprot/P56945

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_014567

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_055382