SMARCE1 (NM_003079) Human Recombinant Protein

• Background:

  The protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins, this protein has no yeast counterpart. [provided by RefSeq, Jul 2008]

• Synonyms:

  BAF57; CSS5

• Gene ID:

  6605

• UniProt:

  Q969G3, A0A024R1S7

• Accession Number mRNA:

  NM_003079

• Chromosomal Location:

  17q21.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Transcription Factors

• Molecular Weight:

  46.5 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  SMARCE1

• Species:

  Human

• Protein ID:

  NP_003070

• Overview:

  Recombinant protein of human SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 (SMARCE1)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/6605

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q969G3

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_003079

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_003070