Peroxiredoxin 2 (PRDX2) (NM_181738) Human Recombinant Protein

• Background:

  This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the antiviral activity of CD8 (+) T-cells. The crystal structure of this protein has been resolved to 2.7 angstroms. This protein prevents hemolytic anemia from oxidative stress by stabilizing hemoglobin, thus making this gene a therapeutic target for patients with hemolytic anemia. This protein may have a proliferative effect and play a role in cancer development or progression. Related pseudogenes have been identified on chromosomes 5, 6, 10 and 13. [provided by RefSeq, Mar 2013]

• Synonyms:

  NKEFB; PRP; PRX2; PRXII; PTX1; TDPX1; TPX1; TSA

• Gene ID:

  7001

• UniProt:

  P32119

• Accession Number mRNA:

  NM_181738

• Chromosomal Location:

  19p13.13

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  15.6 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  PRDX2

• Species:

  Human

• Protein ID:

  NP_859428

• Overview:

  Recombinant protein of human peroxiredoxin 2 (PRDX2), nuclear gene encoding mitochondrial protein, transcript variant 3

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/7001

• Uniprot URL:

  https://www.uniprot.org/uniprot/P32119

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_181738

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_859428