Glutathione Reductase (GSR) (NM_000637) Human Recombinant Protein

• Background:

  This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2010]

• Synonyms:

  GR; GSRD; HEL-75; HEL-S-122m

• Gene ID:

  2936

• UniProt:

  P00390, V9HW90

• Accession Number mRNA:

  NM_000637

• Chromosomal Location:

  8p12

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Glutathione metabolism

• Field of Research:

  Glutathione metabolism

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  56.1 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  GSR

• Species:

  Human

• Protein ID:

  NP_000628

• Overview:

  Recombinant protein of human glutathione reductase (GSR)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/2936

• Uniprot URL:

  https://www.uniprot.org/uniprot/P00390

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_000637

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_000628