Retinol Saturase (RETSAT) (NM_017750) Human Recombinant Protein

• Background:

  Catalyzes the saturation of all-trans-retinol to all-trans-13,14-dihydroretinol. Does not exhibit any activity toward all-trans-retinoic acid, nor 9-cis, 11-cis or 13-cis-retinol isomers. May play a role in the metabolism of vitamin A. Independently of retinol conversion, may regulate liver metabolism upstream of MLXIPL/ChREBP. May play a role in adipocyte differentiation.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  FLJ20296

• Gene ID:

  54884

• UniProt:

  Q6NUM9

• Accession Number mRNA:

  NM_017750

• Chromosomal Location:

  2p11.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Retinol metabolism

• Field of Research:

  Retinol metabolism

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Transmembrane

• Molecular Weight:

  66.6 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  RETSAT

• Species:

  Human

• Protein ID:

  NP_060220

• Overview:

  Recombinant protein of human retinol saturase (all-trans-retinol 13, 14-reductase) (RETSAT)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/54884

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q6NUM9

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_017750

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_060220