Mannan Binding Lectin (MBL2) (NM_000242) Human Recombinant Protein

• Background:

  This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes and binds to mannose and N-acetylglucosamine on many microorganisms, including bacteria, yeast, and viruses including influenza virus, HIV and SARS-CoV. This binding activates the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases. [provided by RefSeq, Jun 2020]

• Synonyms:

  COLEC1; HSMBPC; MBL; MBL2D; MBP; MBP-C; MBP1; MBPD

• Gene ID:

  4153

• UniProt:

  P11226

• Accession Number mRNA:

  NM_000242

• Chromosomal Location:

  10q21.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Complement and coagulation cascades

• Field of Research:

  Complement and coagulation cascades

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  24 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  MBL2

• Species:

  Human

• Protein ID:

  NP_000233

• Overview:

  Recombinant protein of human mannose-binding lectin (protein C) 2, soluble (opsonic defect) (MBL2)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/4153

• Uniprot URL:

  https://www.uniprot.org/uniprot/P11226

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_000242

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_000233