SHARP2 (BHLHE40) (NM_003670) Human Recombinant Protein

• Background:

  This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with ARNTL or compete for E-box binding sites in the promoter of PER1 and repress CLOCK/ARNTL's transactivation of PER1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. [provided by RefSeq, Feb 2014]

• Synonyms:

  BHLHB2; Clast5; DEC1; HLHB2; SHARP-2; SHARP2; STRA13; Stra14

• Gene ID:

  8553

• UniProt:

  O14503, Q6IB83

• Accession Number mRNA:

  NM_003670

• Chromosomal Location:

  3p26.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Circadian rhythm - mammal

• Field of Research:

  Circadian rhythm - mammal

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Transcription Factors

• Molecular Weight:

  45.3 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  BHLHE40

• Species:

  Human

• Protein ID:

  NP_003661

• Overview:

  Recombinant protein of human basic helix-loop-helix family, member e40 (BHLHE40)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/8553

• Uniprot URL:

  https://www.uniprot.org/uniprot/O14503

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_003670

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_003661