SRP1 (KPNA1) (NM_002264) Human Recombinant Protein

• Background:

  The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. This protein interacts with the recombination activating gene 1 (RAG1) protein and is a putative substrate of the RAG1 ubiquitin ligase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

• Synonyms:

  IPOA5; NPI-1; RCH2; SRP1

• Gene ID:

  3836

• UniProt:

  P52294

• Accession Number mRNA:

  NM_002264

• Chromosomal Location:

  3q21.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Molecular Weight:

  60 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  KPNA1

• Species:

  Human

• Protein ID:

  NP_002255

• Overview:

  Recombinant protein of human karyopherin alpha 1 (importin alpha 5) (KPNA1), transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/3836

• Uniprot URL:

  https://www.uniprot.org/uniprot/P52294

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_002264

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_002255