PRPH2 (NM_000322) Human Recombinant Protein

• Background:

  The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein found in the outer segment of both rod and cone photoreceptor cells. It may function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. This protein is essential for disk morphogenesis. Defects in this gene are associated with both central and peripheral retinal degenerations. Some of the various phenotypically different disorders are autosomal dominant retinitis pigmentosa, progressive macular degeneration, macular dystrophy and retinitis pigmentosa digenic. [provided by RefSeq, Jul 2008]

• Synonyms:

  AOFMD; AVMD; CACD2; DS; MDBS1; PRPH; rd2; RDS; RP7; TSPAN22

• Gene ID:

  5961

• UniProt:

  P23942

• Accession Number mRNA:

  NM_000322

• Chromosomal Location:

  6p21.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Amyotrophic lateral sclerosis (ALS)

• Field of Research:

  Amyotrophic lateral sclerosis (ALS)

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Transmembrane

• Molecular Weight:

  39.1 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  PRPH2

• Species:

  Human

• Protein ID:

  NP_000313

• Overview:

  Recombinant protein of human peripherin 2 (retinal degeneration, slow) (PRPH2)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/5961

• Uniprot URL:

  https://www.uniprot.org/uniprot/P23942

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_000322

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_000313