MC2 receptor (MC2R) (NM_000529) Human Recombinant Protein

• Background:

  MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC) . MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency. Alternate transcript variants have been found for this gene. [provided by RefSeq, May 2014]

• Synonyms:

  ACTHR

• Gene ID:

  4158

• UniProt:

  Q01718

• Accession Number mRNA:

  NM_000529

• Chromosomal Location:

  18p11.21

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Neuroactive ligand-receptor interaction

• Field of Research:

  Neuroactive ligand-receptor interaction

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, GPCR, Transmembrane

• Molecular Weight:

  33.7 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  MC2R

• Species:

  Human

• Protein ID:

  NP_000520

• Overview:

  Recombinant protein of human melanocortin 2 receptor (adrenocorticotropic hormone) (MC2R)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/4158

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q01718

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_000529

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_000520