PBX1 (NM_002585) Human Recombinant Protein

• Background:

  This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis and required for skeletal patterning and programming. A chromosomal translocation, t (1;19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017]

• Synonyms:

  CAKUHED

• Gene ID:

  5087

• UniProt:

  P40424, A1MJ41, A8K5V0

• Accession Number mRNA:

  NM_002585

• Chromosomal Location:

  1q23.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Stem cell - Pluripotency, Transcription Factors

• Molecular Weight:

  46.4 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  PBX1

• Species:

  Human

• Protein ID:

  NP_002576

• Overview:

  Recombinant protein of human pre-B-cell leukemia homeobox 1 (PBX1)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/5087

• Uniprot URL:

  https://www.uniprot.org/uniprot/P40424

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_002585

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_002576