GM CSF (CSF2) (NM_000758) Human Recombinant Protein

• Background:

  The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. This gene plays a role in promoting tissue inflammation. Elevated levels of cytokines, including the one produced by this gene, have been detected in SARS-CoV-2 infected patients that develop acute respiratory distress syndrome. Mice deficient in this gene or its receptor develop pulmonary alveolar proteinosis. [provided by RefSeq, Aug 2020]

• Synonyms:

  CSF; GMCSF

• Gene ID:

  1437

• UniProt:

  P04141

• Accession Number mRNA:

  NM_000758

• Chromosomal Location:

  5q31.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Cytokine-cytokine receptor interaction, Fc epsilon RI signaling pathway, Hematopoietic cell lineage, Jak-STAT signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway

• Field of Research:

  Cytokine-cytokine receptor interaction, Fc epsilon RI signaling pathway, Hematopoietic cell lineage, Jak-STAT signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein

• Molecular Weight:

  14.4 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  CSF2

• Species:

  Human

• Protein ID:

  NP_000749

• Overview:

  Recombinant protein of human colony stimulating factor 2 (granulocyte-macrophage) (CSF2)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/1437

• Uniprot URL:

  https://www.uniprot.org/uniprot/P04141

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_000758

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_000749