TNFSF9 (NM_003811) Human Recombinant Protein

• Background:

  The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.[provided by RefSeq, Oct 2008]

• Synonyms:

  4-1BB-L; CD137L; TNLG5A

• Gene ID:

  8744

• UniProt:

  P41273, A0A0U5J8I0

• Accession Number mRNA:

  NM_003811

• Chromosomal Location:

  19p13.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Cytokine-cytokine receptor interaction

• Field of Research:

  Cytokine-cytokine receptor interaction

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Transmembrane

• Molecular Weight:

  26.4 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  TNFSF9

• Species:

  Human

• Protein ID:

  NP_003802

• Overview:

  Recombinant protein of human tumor necrosis factor (ligand) superfamily, member 9 (TNFSF9)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/8744

• Uniprot URL:

  https://www.uniprot.org/uniprot/P41273

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_003811

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_003802