DDR2 (NM_006182) Human Recombinant Protein

• Background:

  This gene encodes a member of the discoidin domain receptor subclass of the receptor tyrosine kinase (RTKs) protein family. RTKs play a key role in the communication of cells with their microenvironment. The encoded protein is a collagen-induced receptor that activates signal transduction pathways involved in cell adhesion, proliferation, and extracellular matrix remodeling. This protein is expressed in numerous cell types and may alos be involved in wound repair and regulate tumor growth and invasiveness. Mutations in this gene are the cause of short limb-hand type spondylometaepiphyseal dysplasia. [provided by RefSeq, Aug 2017]

• Synonyms:

  MIG20a; NTRKR3; TKT; TYRO10; WRCN

• Gene ID:

  4921

• UniProt:

  Q16832, A0A024R906

• Accession Number mRNA:

  NM_006182

• Chromosomal Location:

  1q23.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Protein Kinase, Transmembrane

• Molecular Weight:

  94.3 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  DDR2

• Species:

  Human

• Protein ID:

  NP_006173

• Overview:

  Recombinant protein of human discoidin domain receptor tyrosine kinase 2 (DDR2), transcript variant 2

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/4921

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q16832

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_006182

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_006173