OPA1 (NM_130832) Human Recombinant Protein

• Background:

  The protein encoded by this gene is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. The encoded protein localizes to the inner mitochondrial membrane and helps regulate mitochondrial stability and energy output. This protein also sequesters cytochrome c. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. [provided by RefSeq, Aug 2017]

• Synonyms:

  BERHS; largeG; MGM1; MTDPS14; NPG; NTG

• Gene ID:

  4976

• UniProt:

  E5KLK0

• Accession Number mRNA:

  NM_130832

• Chromosomal Location:

  3q29

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Molecular Weight:

  109.2 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  OPA1

• Species:

  Human

• Protein ID:

  NP_570845

• Overview:

  Recombinant protein of human optic atrophy 1 (autosomal dominant) (OPA1), nuclear gene encoding mitochondrial protein, transcript variant 3

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/4976

• Uniprot URL:

  https://www.uniprot.org/uniprot/E5KLK0

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_130832

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_570845