HSD11B1 (NM_181755) Human Recombinant Protein

• Background:

  The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) ) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, May 2011]

• Synonyms:

  11-beta-HSD1; 11-DH; CORTRD2; HDL; HSD11; HSD11B; HSD11L; SDR26C1

• Gene ID:

  3290

• UniProt:

  P28845, X5D2L1

• Accession Number mRNA:

  NM_181755

• Chromosomal Location:

  1q32.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Androgen and estrogen metabolism, C21-Steroid hormone metabolism, Metabolic pathways

• Field of Research:

  Androgen and estrogen metabolism, C21-Steroid hormone metabolism, Metabolic pathways

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Activity:

  29674492

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Transmembrane

• Molecular Weight:

  32.2 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  HSD11B1

• Species:

  Human

• Protein ID:

  NP_861420

• Overview:

  Recombinant protein of human hydroxysteroid (11-beta) dehydrogenase 1 (HSD11B1), transcript variant 2

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/3290

• Uniprot URL:

  https://www.uniprot.org/uniprot/P28845

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_181755

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_861420