NANOS2 (NM_001029861) Human Recombinant Protein

• Background:

  Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state (By similarity) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  NOS2; ZC2HC12B

• Gene ID:

  339345

• UniProt:

  P60321

• Accession Number mRNA:

  NM_001029861

• Chromosomal Location:

  19q13.32

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Molecular Weight:

  15 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  NANOS2

• Species:

  Human

• Protein ID:

  NP_001025032

• Overview:

  Recombinant protein of human nanos homolog 2 (Drosophila) (NANOS2)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/339345

• Uniprot URL:

  https://www.uniprot.org/uniprot/P60321

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001029861

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001025032