Activin Receptor Type IIB (ACVR2B) (NM_001106) Human Recombinant Protein

• Background:

  Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq, Jul 2008]

• Synonyms:

  ActR-IIB; ACTRIIB; HTX4

• Gene ID:

  93

• UniProt:

  Q13705

• Accession Number mRNA:

  NM_001106

• Chromosomal Location:

  3p22.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Cytokine-cytokine receptor interaction, TGF-beta signaling pathway

• Field of Research:

  Cytokine-cytokine receptor interaction, TGF-beta signaling pathway

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Protein Kinase, Transmembrane

• Molecular Weight:

  57.5 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  ACVR2B

• Species:

  Human

• Protein ID:

  NP_001097

• Overview:

  Recombinant protein of human activin A receptor, type IIB (ACVR2B)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/93

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q13705

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001106

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001097