SOD2 (NM_001024465) Human Recombinant Protein

• Background:

  This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. [provided by RefSeq, Apr 2016]

• Synonyms:

  GClnc1; IPO-B; IPOB; Mn-SOD; MNSOD; MVCD6

• Gene ID:

  6648

• UniProt:

  P04179, A0A384NL29

• Accession Number mRNA:

  NM_001024465

• Chromosomal Location:

  6q25.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Huntington's disease

• Field of Research:

  Huntington's disease

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Transcription Factors

• Molecular Weight:

  22.2 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  SOD2

• Species:

  Human

• Protein ID:

  NP_001019636

• Overview:

  Recombinant protein of human superoxide dismutase 2, mitochondrial (SOD2), nuclear gene encoding mitochondrial protein, transcript variant 2

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/6648

• Uniprot URL:

  https://www.uniprot.org/uniprot/P04179

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001024465

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001019636