PTPRN2 (NM_130842) Human Recombinant Protein

• Background:

  This gene encodes a protein with sequence similarity to receptor-like protein tyrosine phosphatases. However, tyrosine phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol phosphatase with the ability to dephosphorylate phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-diphosphate, and this function may be involved in the regulation of insulin secretion. This protein has been identified as an autoantigen in insulin-dependent diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

• Synonyms:

  IA-2beta; IAR; ICAAR; PTPRP; R-PTP-N2

• Gene ID:

  5799

• UniProt:

  Q92932

• Accession Number mRNA:

  NM_130842

• Chromosomal Location:

  7q36.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Type I diabetes mellitus

• Field of Research:

  Type I diabetes mellitus

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Phosphatase

• Molecular Weight:

  109.4 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  PTPRN2

• Species:

  Human

• Protein ID:

  NP_570857

• Overview:

  Recombinant protein of human protein tyrosine phosphatase, receptor type, N polypeptide 2 (PTPRN2), transcript variant 2

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/5799

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q92932

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_130842

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_570857