ACSL5 (NM_203379) Human Recombinant Protein

• Background:

  The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Synonyms:

  ACS2; ACS5; FACL5

• Gene ID:

  51703

• UniProt:

  Q9ULC5

• Accession Number mRNA:

  NM_203379

• Chromosomal Location:

  10q25.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Adipocytokine signaling pathway, Fatty acid metabolism, Metabolic pathways, PPAR signaling pathway

• Field of Research:

  Adipocytokine signaling pathway, Fatty acid metabolism, Metabolic pathways, PPAR signaling pathway

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Transmembrane

• Molecular Weight:

  75.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  ACSL5

• Species:

  Human

• Protein ID:

  NP_976313

• Overview:

  Recombinant protein of human acyl-CoA synthetase long-chain family member 5 (ACSL5), transcript variant 2

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/51703

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9ULC5

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_203379

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_976313