DIAPH1 (NM_001079812) Human Recombinant Protein

• Background:

  This gene is a homolog of the Drosophila diaphanous gene, and has been linked to autosomal dominant, fully penetrant, nonsyndromic sensorineural progressive low-frequency hearing loss. Actin polymerization involves proteins known to interact with diaphanous protein in Drosophila and mouse. It has therefore been speculated that this gene may have a role in the regulation of actin polymerization in hair cells of the inner ear. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Synonyms:

  DFNA1; DIA1; DRF1; hDIA1; LFHL1; SCBMS

• Gene ID:

  1729

• UniProt:

  O60610

• Accession Number mRNA:

  NM_001079812

• Chromosomal Location:

  5q31.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Focal adhesion, Regulation of actin cytoskeleton

• Field of Research:

  Focal adhesion, Regulation of actin cytoskeleton

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Stem cell - Pluripotency

• Molecular Weight:

  140.1 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  DIAPH1

• Species:

  Human

• Protein ID:

  NP_001073280

• Overview:

  Recombinant protein of human diaphanous homolog 1 (Drosophila) (DIAPH1), transcript variant 2

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/1729

• Uniprot URL:

  https://www.uniprot.org/uniprot/O60610

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001079812

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001073280