GALNT1 (NM_020474) Human Recombinant Protein

• Background:

  This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. Transcript variants derived from this gene that utilize alternative polyA signals have been described in the literature. [provided by RefSeq, Jul 2008]

• Synonyms:

  GALNAC-T1

• Gene ID:

  2589

• UniProt:

  Q10472, A0A024RC48, Q05BM8

• Accession Number mRNA:

  NM_020474

• Chromosomal Location:

  18q12.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Metabolic pathways, O-Glycan biosynthesis

• Field of Research:

  Metabolic pathways, O-Glycan biosynthesis

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Secreted Protein, Transmembrane

• Molecular Weight:

  64 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  GALNT1

• Species:

  Human

• Protein ID:

  NP_065207

• Overview:

  Recombinant protein of human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1) (GALNT1)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/2589

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q10472

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_020474

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_065207