P18 INK4c (CDKN2C) (NM_078626) Human Recombinant Protein

• Background:

  The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]

• Synonyms:

  INK4C; p18; p18-INK4C

• Gene ID:

  1031

• UniProt:

  P42773, Q6ICV4

• Accession Number mRNA:

  NM_078626

• Chromosomal Location:

  1p32.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Cell cycle

• Field of Research:

  Cell cycle

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  17.9 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  CDKN2C

• Species:

  Human

• Protein ID:

  NP_523240

• Overview:

  Recombinant protein of human cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) (CDKN2C), transcript variant 2

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/1031

• Uniprot URL:

  https://www.uniprot.org/uniprot/P42773

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_078626

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_523240