Kv beta 2 (KCNAB2) (NM_172130) Human Recombinant Protein

• Background:

  Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog (s) . This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member alters functional properties of the KCNA4 gene product. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2010]

• Synonyms:

  AKR6A5; HKvbeta2; HKvbeta2.1; HKvbeta2.2; KCNA2B; KV-BETA-2

• Gene ID:

  8514

• UniProt:

  Q13303, B2R776

• Accession Number mRNA:

  NM_172130

• Chromosomal Location:

  1p36.31

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Ion Channels: Other

• Molecular Weight:

  39.1 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  KCNAB2

• Species:

  Human

• Protein ID:

  NP_742128

• Overview:

  Recombinant protein of human potassium voltage-gated channel, shaker-related subfamily, beta member 2 (KCNAB2), transcript variant 2

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/8514

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q13303

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_172130

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_742128