Complement C3 (C3) (NM_000064) Human Recombinant Protein

• Background:

  Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numerous peptide products. The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical hemolytic uremic syndrome and age-related macular degeneration in human patients. [provided by RefSeq, Nov 2015]

• Synonyms:

  AHUS5; ARMD9; ASP; C3a; C3b; CPAMD1; HEL-S-62p

• Gene ID:

  718

• UniProt:

  P01024, V9HWA9, B4DR57

• Accession Number mRNA:

  NM_000064

• Chromosomal Location:

  19p13.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Complement and coagulation cascades, Systemic lupus erythematosus

• Field of Research:

  Complement and coagulation cascades, Systemic lupus erythematosus

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  187 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  C3

• Species:

  Human

• Protein ID:

  NP_000055

• Overview:

  Recombinant protein of human complement component 3 (C3)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/718

• Uniprot URL:

  https://www.uniprot.org/uniprot/P01024

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_000064

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_000055