UBE3C (NM_014671) Human Recombinant Protein

• Background:

  E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains. Has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  HECTH2

• Gene ID:

  9690

• UniProt:

  Q15386

• Accession Number mRNA:

  NM_014671

• Chromosomal Location:

  7q36.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Ubiquitin mediated proteolysis

• Field of Research:

  Ubiquitin mediated proteolysis

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  123.7 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  UBE3C

• Species:

  Human

• Protein ID:

  NP_055486

• Overview:

  Recombinant protein of human ubiquitin protein ligase E3C (UBE3C)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/9690

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q15386

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_014671

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_055486