FE65 (APBB1) (NM_145689) Human Recombinant Protein

• Background:

  The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012]

• Synonyms:

  FE65; MGC:9072; RIR

• Gene ID:

  322

• UniProt:

  O00213

• Accession Number mRNA:

  NM_145689

• Chromosomal Location:

  11p15.4

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Alzheimer's disease

• Field of Research:

  Alzheimer's disease

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Transcription Factors

• Molecular Weight:

  76.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  APBB1

• Species:

  Human

• Protein ID:

  NP_663722

• Overview:

  Recombinant protein of human amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) (APBB1), transcript variant 2

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/322

• Uniprot URL:

  https://www.uniprot.org/uniprot/O00213

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_145689

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_663722