FTS (AKTIP) (NM_022476) Human Recombinant Protein

• Background:

  The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB) /Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

• Synonyms:

  FT1; FTS

• Gene ID:

  64400

• UniProt:

  Q9H8T0, A0A024R6T5

• Accession Number mRNA:

  NM_022476

• Chromosomal Location:

  16q12.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Molecular Weight:

  32.9 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  AKTIP

• Species:

  Human

• Protein ID:

  NP_071921

• Overview:

  Recombinant protein of human AKT interacting protein (AKTIP), transcript variant 2

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/64400

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9H8T0

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_022476

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_071921