Lipin 3 (LPIN3) (NM_022896) Human Recombinant Protein

• Background:

  The protein encoded by this gene is a member of the lipin family of proteins, and all family members share strong homology in their C-terminal region. This protein is thought to form hetero-oligomers with other lipin family members, while one family member, lipin 1, can also form homo-oligomers. This protein contains conserved motifs for phosphatidate phosphatase 1 (PAP1) activity as well as a domain that interacts with a transcriptional co-activator. Lipin complexes act in the cytoplasm to catalyze the dephosphorylation of phosphatidic acid to produce diacylglycerol, which is the precursor of both triglycerides and phospholipids. Lipin complexes are also thought to regulate gene expression as transcriptional co-activators in the nucleus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

• Synonyms:

  DJ620E11.2; LIPN3L; SMP2

• Gene ID:

  64900

• UniProt:

  Q9BQK8

• Accession Number mRNA:

  NM_022896

• Chromosomal Location:

  20q12

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Molecular Weight:

  93.4 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  LPIN3

• Species:

  Human

• Protein ID:

  NP_075047

• Overview:

  Recombinant protein of human lipin 3 (LPIN3)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/64900

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9BQK8

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_022896

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_075047