Glutaredoxin 2 (GLRX2) (NM_016066) Human Recombinant Protein

• Background:

  The protein encoded by this gene is a member of the glutaredoxin family of proteins, which maintain cellular thiol homeostasis. These proteins are thiol-disulfide oxidoreductases that use a glutathione-binding site and one or two active cysteines in their active site. This gene undergoes alternative splicing to produce multiple isoforms, one of which is ubiquitously expressed and localizes to mitochondria, where it functions in mitochondrial redox homeostasis and is important for the protection against and recovery from oxidative stress. Other isoforms, which have more restrictive expression patterns, show cytosolic and nuclear localization, and are thought to function in cellular differentiation and transformation, possibly with a role in tumor progression. [provided by RefSeq, Aug 2011]

• Synonyms:

  CGI-133; GRX2

• Gene ID:

  51022

• UniProt:

  Q9NS18

• Accession Number mRNA:

  NM_016066

• Chromosomal Location:

  1q31.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Transcription Factors

• Molecular Weight:

  18.5 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  GLRX2

• Species:

  Human

• Protein ID:

  NP_057150

• Overview:

  Recombinant protein of human glutaredoxin 2 (GLRX2), transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/51022

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9NS18

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_016066

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_057150