PIP5KI gamma (PIP5K1C) (NM_012398) Human Recombinant Protein

• Background:

  This locus encodes a type I phosphatidylinositol 4-phosphate 5-kinase. The encoded protein catalyzes phosphorylation of phosphatidylinositol 4-phosphate, producing phosphatidylinositol 4,5-bisphosphate. This enzyme is found at synapses and has been found to play roles in endocytosis and cell migration. Mutations at this locus have been associated with lethal congenital contractural syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Sep 2010]

• Synonyms:

  LCCS3; PIP5K-GAMMA; PIP5K1-gamma; PIP5Kgamma

• Gene ID:

  23396

• UniProt:

  O60331

• Accession Number mRNA:

  NM_012398

• Chromosomal Location:

  19p13.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Endocytosis, Fc gamma R-mediated phagocytosis, Focal adhesion, Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system, Regulation of actin cytoskeleton

• Field of Research:

  Endocytosis, Fc gamma R-mediated phagocytosis, Focal adhesion, Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system, Regulation of actin cytoskeleton

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  73.1 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  PIP5K1C

• Species:

  Human

• Protein ID:

  NP_036530

• Overview:

  Recombinant protein of human phosphatidylinositol-4-phosphate 5-kinase, type I, gamma (PIP5K1C)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/23396

• Uniprot URL:

  https://www.uniprot.org/uniprot/O60331

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_012398

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_036530