Histone H2A Bbd (H2AFB1) (NM_001017990) Human Recombinant Protein

• Background:

  Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4) . The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. This gene is part of a region that is repeated three times on chromosome X, once in intron 22 of the F8 gene and twice closer to the Xq telomere. This record represents the most centromeric copy which is in intron 22 of the F8 gene. [provided by RefSeq, Oct 2015]

• Synonyms:

  H2A.B; H2A.Bbd; H2AFB1

• Gene ID:

  474382

• UniProt:

  P0C5Y9

• Accession Number mRNA:

  NM_001017990

• Chromosomal Location:

  Xq28

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Systemic lupus erythematosus

• Field of Research:

  Systemic lupus erythematosus

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Molecular Weight:

  12.5 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  H2AB1

• Species:

  Human

• Protein ID:

  NP_001017990

• Overview:

  Recombinant protein of human H2A histone family, member B1 (H2AFB1)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/474382

• Uniprot URL:

  https://www.uniprot.org/uniprot/P0C5Y9

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001017990

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001017990