GLB1 (NM_000404) Human Recombinant Protein

• Background:

  This gene encodes a member of the glycosyl hydrolase 35 family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature lysosomal enzyme. This enzyme catalyzes the hydrolysis of a terminal beta-linked galactose residue from ganglioside substrates and other glycoconjugates. Mutations in this gene may result in GM1-gangliosidosis and Morquio B syndrome. [provided by RefSeq, Nov 2015]

• Synonyms:

  EBP; ELNR1; MPS4B

• Gene ID:

  2720

• UniProt:

  P16278

• Accession Number mRNA:

  NM_000404

• Chromosomal Location:

  3p22.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Galactose metabolism, Glycosaminoglycan degradation, Glycosphingolipid biosynthesis - ganglio series, Lysosome, Metabolic pathways, Other glycan degradation, Sphingolipid metabolism

• Field of Research:

  Galactose metabolism, Glycosaminoglycan degradation, Glycosphingolipid biosynthesis - ganglio series, Lysosome, Metabolic pathways, Other glycan degradation, Sphingolipid metabolism

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  75.9 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  GLB1

• Species:

  Human

• Protein ID:

  NP_000395

• Overview:

  Recombinant protein of human galactosidase, beta 1 (GLB1), transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/2720

• Uniprot URL:

  https://www.uniprot.org/uniprot/P16278

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_000404

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_000395