Doublecortin (DCX) (NM_178151) Human Recombinant Protein

• Background:

  This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, cognitive disability, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]

• Synonyms:

  DBCN; DC; LISX; SCLH; XLIS

• Gene ID:

  1641

• UniProt:

  O43602

• Accession Number mRNA:

  NM_178151

• Chromosomal Location:

  Xq23

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  39.9 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  DCX

• Species:

  Human

• Protein ID:

  NP_835364

• Overview:

  Recombinant protein of human doublecortin (DCX), transcript variant 4

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/1641

• Uniprot URL:

  https://www.uniprot.org/uniprot/O43602

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_178151

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_835364