MNK2 (MKNK2) (NM_199054) Human Recombinant Protein

• Background:

  This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G) . This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC (VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization. [provided by RefSeq, Aug 2011]

• Synonyms:

  GPRK7; MNK2

• Gene ID:

  2872

• UniProt:

  Q9HBH9, B3KS07

• Accession Number mRNA:

  NM_199054

• Chromosomal Location:

  19p13.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Insulin signaling pathway, MAPK signaling pathway

• Field of Research:

  Insulin signaling pathway, MAPK signaling pathway

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Protein Kinase

• Molecular Weight:

  51.7 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  MKNK2

• Species:

  Human

• Protein ID:

  NP_951009

• Overview:

  Recombinant protein of human MAP kinase interacting serine/threonine kinase 2 (MKNK2), transcript variant 2

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/2872

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9HBH9

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_199054

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_951009