Vasopressin (AVP) (NM_000490) Human Recombinant Protein

• Background:

  This gene encodes a member of the vasopressin/oxytocin family and preproprotein that is proteolytically processed to generate multiple protein products. These products include the neuropeptide hormone arginine vasopressin, and two other peptides, neurophysin 2 and copeptin. Arginine vasopressin is a posterior pituitary hormone that is synthesized in the supraoptic nucleus and paraventricular nucleus of the hypothalamus. Along with its carrier protein, neurophysin 2, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis where it is either stored or secreted into the bloodstream. The precursor is thought to be activated while it is being transported along the axon to the posterior pituitary. Arginine vasopressin acts as a growth factor by enhancing pH regulation through acid-base transport systems. It has a direct antidiuretic action on the kidney, and also causes vasoconstriction of the peripheral vessels. This hormone can contract smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. Mutations in this gene cause autosomal dominant neurohypophyseal diabetes insipidus (ADNDI) . This gene is present in a gene cluster with the related gene oxytocin on chromosome 20. [provided by RefSeq, Nov 2015]

• Synonyms:

  ADH; ARVP; AVP-NPII; AVRP; VP

• Gene ID:

  551

• UniProt:

  P01185, X5DQP6

• Accession Number mRNA:

  NM_000490

• Chromosomal Location:

  20p13

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Secreted Protein

• Molecular Weight:

  17.3 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  AVP

• Species:

  Human

• Protein ID:

  NP_000481

• Overview:

  Recombinant protein of human arginine vasopressin (AVP)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/551

• Uniprot URL:

  https://www.uniprot.org/uniprot/P01185

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_000490

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_000481